Effect of Tumour-induced Osteolysis and Efficacy of Anti-resorptive and Chemotherapeutic Treatments in Metastatic Bone Disease
نویسنده
چکیده
INTRODUCTION Skeletal metastases are the most common complication of malignancies such as breast and prostate cancers [1]. In tumour-induced osteolysis, bone resorption is increased by the neoplastic activation of osteoclasts which results in rapid bone loss, change in the architectural integrity and ultimately, the load-bearing capacity of the affected bone. Fracture risk is increased by this deterioration in bone structure. The purpose of this pilot study is to assess the efficacy of anti-resorptive (Ibandronate) and chemotherapeutic (Paclitaxel) drug treatments in preserving skeletal integrity in terms of structural and biomechanical parameters, using an experimental model of tumour-induced osteolysis.
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تاریخ انتشار 2009